EPAC 5376753
CAS No. : 302826-61-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $128 | In-stock |
| 10mg | $193 | In-stock |
| 25mg | $386 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $868 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111446 |
| M.Wt: | 367.21 |
| Formula: | C15H8Cl2N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
EPAC 5376753, a 2-Thiobarbituric acid (HY-77962) derivative, is a selective and allosteric Epac inhibitor. EPAC 5376753 inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. EPAC 5376753 does not inhibit PKA and adenylyl cyclases[1].
IC50 & Target:IC50: 4 µM (Epac)[1]
In Vitro:EPAC 5376753 (1-100 μM; 48 h) above 50 μM will significantly inhibit cell activity, and below 50 μM will have no effect on cell activity[1].
Epac is a key mediator of cAMP signaling. EPAC 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1].
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