P7C3
CAS No. : 301353-96-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $176 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $480 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15976 |
| M.Wt: | 474.19 |
| Formula: | C21H18Br2N2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 can be used for the research of neurodegenerative diseases, including Parkinson's disease[1][2][3].
In Vitro: P7C3 inhibits LPS-induced production of pro-inflammatory factors in BV2 cells[3].
P7C3 markedly reduces the protein levels of iNOS and COX-2 in a dose-dependent manner without affecting the cell viability in the LPS (100 ng/mL)-stimulated BV2 cells[3].
P7C3 inhibits LPS-induced nuclear translocation of NF-κB p65 subunit in BV2 cells[3].
P7C3 suppresses LPS-induced degradation of inhibitory κB alpha (IκBα) by inhibiting IκB kinase (IKK) activation[3].
In Vivo: P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo[3].
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