CH-223191
CAS No. : 301326-22-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $122 | In-stock |
| 25mg | $246 | In-stock |
| 50mg | $382 | In-stock |
| 100mg | $622 | In-stock |
| 200mg | $845 | In-stock |
| 500mg | $1266 | In-stock |
| 1g | $1900 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-12684 |
| M.Wt: | 333.39 |
| Formula: | C19H19N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1]. In Vitro:CH-223191 (0.1-10 μM; pre-treated 1 hour) inhibits TCDD-caused cytochrome P450 1A1 mRNA expression in a in dose-dependent manner[1]. CH-223191 (0.1-10 μM; pre-treated 1 hour) causes a concentration-dependent inhibition of TCDD-induced cytochrome P450 enzyme activity[1]. In Vivo:CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice[1].
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