RH01386
CAS No. : 301177-36-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $440 | In-stock |
| 25mg | $730 | In-stock |
| 50mg | $980 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-124771 |
| M.Wt: | 424.40 |
| Formula: | C18H15F3N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1]. IC50 & Target: ER stress-induced β cell dysfunction[1] In Vitro: RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1]. RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1].
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