XCT0135908
CAS No. : 300837-31-4
(Synonyms: XCT)
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| Cat. No. : | HY-119612 |
| M.Wt: | 345.40 |
| Formula: | C21H19N3O2 |
| Purity: | >98 % |
| Solubility: |
XCT0135908 (XCT) is a selective Nurr1-RXRα activator with an EC50 value of 0.3 μM in human dopaminergic SH-SY5Y cells. XCT0135908 protects dopaminergic cells against the Parkinson’s disease-related toxin MPP+. XCT0135908 can be used for the research of Parkinson’s disease[1].
In Vitro:XCT0135908 (Compound 7a) (0.5-12.5 μM; overnight) activates the Nurr1-RXRα heterodimer in human dopaminergic SH-SY5Y cells with an EC50 of 0.3 μM[1].
XCT0135908 (0.5-12.5 μM; 12 h) selectively activates Nurr1-RXRα and Nur77-RXRα heterodimers (but not other RXRα heterodimers or homodimers) in human dopaminergic SH-SY5Y cells, with greater activation of Nur77GAL4-RXRαVP16 than Nurr1GAL4-RXRαVP16[1].
XCT0135908 (12.5-50 μM) protects mouse Neuro-2a neuroblast cells from MPP+-induced toxicity at concentrations of 12.5 μM and 50 μM, with no observed toxicity at 50 μM[1].
XCT0135908 (0.5-12.5 μM; 24 h) induces a moderate concentration-dependent increase in SREBP-1c expression in human HepG2 hepatic cells, with a maximal ~5-fold increase at 12.5 μM[1].
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