Apcin
CAS No. : 300815-04-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $52 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $389 | In-stock |
| 50mg | $616 | In-stock |
| 100mg | $990 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110287 |
| M.Wt: | 438.65 |
| Formula: | C13H14Cl3N7O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3].
In Vitro: Apcin (25-50 μM; 48 hours) significantly increases MM apoptosis combining with proTAME (6, 12 μM)[3].
Apcin (25 μM; 2-14 hours) induces slippage more slowly[2].
Apcin (50-200 μM) stabilizes cycB1-NT and securin most effectively, with somewhat weaker effects against full-length cyclin B1[1].
Apcin (1.5-200 μM; 18 hours) synergizes with proTAME (a cell-permeable TAME prodrug) to prolong mitotic duration in RPE1 cells[1].
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