OAC1
CAS No. : 300586-90-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $264 | In-stock |
| 50mg | $456 | In-stock |
| 100mg | $684 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12303 |
| M.Wt: | 237.26 |
| Formula: | C14H11N3O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL |
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1][2].
In Vitro:OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies[1].
OAC1 (1 µM; 2 d; human IMR90 fibroblast cells) activates endogenous Oct4, Nanog, Sox2, and Tet1 expression[1].
OAC1 (500 nM; 4 d; CD34+ cells) increases numbers of phenotypic hematopoietic stem cells (HSC) and functional Hematopoietic progenitor cells (HPC)[2].
OAC1 (500 nM; 4 d; CD34+ cells) activates OCT4 through upregulation of HOXB4 expression to expand hematopoietic stem cells (HSC)[2].
In Vivo:OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice[2].
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