| Size | Price | Stock |
|---|---|---|
| 5mg | $153 | In-stock |
| 10mg | $245 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $784 | In-stock |
| 100mg | $1254 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-10595 |
| M.Wt: | 378.51 |
| Formula: | C18H22N2O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2].
IC50 & Target: EC50: 54 nM (glucokinase)[1]
In Vitro: RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP)[2].
In Vivo: RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice[2].
RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and Cmax (1140 μg/mL) following oral administration (10 mg/kg)[1].
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