RO-28-1675


CAS No. : 300353-13-3

300353-13-3
Price and Availability of CAS No. : 300353-13-3
Size Price Stock
5mg $153 In-stock
10mg $245 In-stock
25mg $490 In-stock
50mg $784 In-stock
100mg $1254 In-stock
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Cat. No. : HY-10595
M.Wt: 378.51
Formula: C18H22N2O3S2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 300353-13-3 :

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2]. IC50 & Target: EC50: 54 nM (glucokinase)[1] In Vitro: RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP)[2].
In Vivo: RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice[2].
RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and Cmax (1140 μg/mL) following oral administration (10 mg/kg)[1].

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