(E/Z)-Mirin
CAS No. : 299953-00-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $150 | In-stock |
| 50mg | $240 | In-stock |
| 100mg | $390 | In-stock |
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| Cat. No. : | HY-117693 |
| M.Wt: | 220.25 |
| Formula: | C10H8N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].
In Vitro:Mirin inhibits H2AX phosphorylation with an IC50 of 66 μM. Mirin also inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2, as well as MRN-dependent autophosphorylation of ATM at Ser1981 in DSB reactions. Mirin at concentrations of 50 μM and 100 μM induces significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells[1].
BRCA2-deficient cells also show hypersensitivity to the Mre11 inhibitor Mirin[2].
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