YM-202074 (fumarate)
CAS No. : 299900-84-8
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| Cat. No. : | HY-103556 |
| M.Wt: | 1177.34 |
| Formula: | C56H72N8O16S2 |
| Purity: | >98 % |
| Solubility: |
YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
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