trans-3-Indoleacrylic acid
CAS No. : 29953-71-7
| Size | Price | Stock |
|---|---|---|
| 1g | $45 | In-stock |
| 5g | $61 | In-stock |
| 25g | $303 | In-stock |
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| Cat. No. : | HY-W015273A |
| M.Wt: | 187.19 |
| Formula: | C11H9NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis[1]
In Vitro:Trans-3-Indoleacrylic acid activites AHR for increased expression of ALDH1A3, which generates NADH for FSP1-mediated synthesis of coenzyme Q10[1].
Trans-3-Indoleacrylic acid inhibits RSL3 induced ferroptosis in cells HT1080 and 786-O, (50 μM, 24 h),
decreases lipids peroxidation (50 μM, 4 h)[1].
Trans-3-Indoleacrylic acid inhibits IKE-induced (10 μM) ferroptosis in HT29 tumor spheroids (100 μM, 48 h ) and HT29 organoids (100 μM, 72 h ) and promotes tumor growth[1].
In Vivo:Trans-3-Indoleacrylic acid (50 mg/kg, i.p., three times a week) promotes tumor development in HT29 tumor-bearing xenograft nu/nu mice [1].
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