NKY80
CAS No. : 299442-43-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $78 | In-stock |
| 10mg | $121 | In-stock |
| 25mg | $242 | In-stock |
| 50mg | $418 | In-stock |
| 100mg | $638 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103195 |
| M.Wt: | 229.24 |
| Formula: | C12H11N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].
IC50 & Target:IC50: 8.3 µM (AC type V), 132 µM (AC type III) and 1.7 mM (AC type II)[1]
In Vitro: NKY80 (20 μM) blocks the elevations in both LVP and ventricular cAMP levels produced by the maximal concentration (10 nM)[2].
NKY80 (20 μM; 2 hours) completely blocks the increase in both cAMP content and renin release from isolated JG cells[3].
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