UC-514321
CAS No. : 299420-83-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $640 | In-stock |
| 50mg | $980 | In-stock |
| 100mg | $1470 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120395 |
| M.Wt: | 441.56 |
| Formula: | C26H35NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);Ethanol : 50 mg/mL (ultrasonic) |
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1]. In Vitro: UC-514321 increases apoptosis in AML cells not in normal HSPCs[1].
UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently[1].
In Vivo: UC-514321 (2.5 mg/kg, ip, once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284 in AML mice models[1].
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