Phenazine (methylsulfate)
CAS No. : 299-11-6
(Synonyms: 5-Methylphenazinium (methylsulfate))
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| Cat. No. : | HY-W004520 |
| M.Wt: | 306.34 |
| Formula: | C14H14N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell apoptosis, showing antitumor activity[1][2][3].
In Vitro:Phenazine methyl sulfate stimulates proton transport by promoting photosynthetic electron flow[1].
Phenazine methyl sulfate (10 μM, 2-24 h) can quickly disrupt and clear Leishmania amastigotes from macrophages without causing significant harm to the host cells[2].
Phenazine methyl sulfate (2.5-20 μM, 24 h) can inhibit or kill Leishmania promastigotes in a dose-dependent manner[2].
Phenazine methyl sulfate (0-10 μM, 24 h) induces apoptosis in A375, G361, and LOX cells[3].
Phenazine methyl sulfate (5-10 μM, 0-24 h) leads to the upregulation of heat shock, oxidative, and genotoxic stress response gene expression in A375 cells[3].
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