Astringin

Astringin (trans-Astringin) is an orally active natural phenolic stilbene glucoside. Astringin can inhibit the production of oxidative stress, inflammatory factors, etc. Astringin has multiple activities such as anti-oxidation, anti-inflammation, and anti-apoptosis. Astringin is also an inhibitor of ferroptosis. Astringin can be used in the research of diseases such as acute lung injury^[1][2][3][4]. In Vitro:Astringin (0-75 µg/mL; 0-26 h) enhances cell viability, inhibits apoptosis, and suppresses the elevation of ROS and MDA levels as well as the production of inflammatory factors such as TNF-α, IL-1β, and IL-6 in LPS (HY-D1056)-stimulated A549 cells. The mechanism involves the inhibition of the PI3K/AKT/NF-κB pathway^[1].
Astringin (1-100 µM) inhibits lipid peroxidation in Erastin (HY-15763)-treated bone marrow-derived mesenchymal stem cells^[2]. In Vivo:Astringin (10 mg/kg; oral gavage; 4 weeks) can effectively alleviate chromium-induced oxidative stress, inflammation, apoptosis, and renal tissue damage in rats^[3].