Ro 67-7476
CAS No. : 298690-60-5
| Size | Price | Stock |
|---|---|---|
| 2mg | $55 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $363 | In-stock |
| 50mg | $660 | In-stock |
| 100mg | $1100 | In-stock |
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| Cat. No. : | HY-100403 |
| M.Wt: | 319.39 |
| Formula: | C17H18FNO2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL |
Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM[1][2]. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM)[3]. In Vitro:In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5[3]. Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM). The EC50 value of full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC50 for calcium mobilization potentiation[3].Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC50 value of 17.7 μM[3].
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