Carbamazepine
CAS No. : 298-46-4
(Synonyms: CBZ; NSC 169864)
| Size | Price | Stock |
|---|---|---|
| 1g | $8 | In-stock |
| 5g | $10 | In-stock |
| 10g | $12 | In-stock |
| 25g | $21 | In-stock |
| 100g | $26 | In-stock |
| 500g | $129 | In-stock |
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| Cat. No. : | HY-B0246 |
| M.Wt: | 236.27 |
| Formula: | C15H12N2O |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain[1][2][3].
In Vitro: Carbamazepine (0-500 μM, 10 days) inhibits pre-adipocyte differentiation (10 days) and triglyceride accumulation (7 days) in 3T3-L1, 3T3-F442A and T37i cells[4].
Carbamazepine (5-20 μM, 15 min before LPS) inhibits LPS-induced production of NO and iNOS protein, and phosphorylation of Akt in microglial (BV-2) cells[5].
Carbamazepine (20 μM, 15 min before LPS) inhibits LPS-induced COX-2 expression and TNF-α production in microglial (BV-2) cells[5].
In Vivo: Carbamazepine (250 mg/kg, p.o.) promotes liver regeneration and survival in partial hepatectomy (PHx) treated mice[6].
Carbamazepine (0.25%-0.75% for ICR mice, 0.5% and 0.75% for C57bl/6 mice with, in food (w/w)) shows mood-stabilising effects in mice[7].
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