Diapocynin
CAS No. : 29799-22-2
(Synonyms: Dehydrodiacetovanillone)
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| Cat. No. : | HY-121097 |
| M.Wt: | 330.33 |
| Formula: | C18H18O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities[1]. In Vivo:Diapocynin (300 mg/kg; p.o.; every 12 hours for 72 hours) significantly rescues DFP-induced motor impairment, attenuates epileptiform spiking during the first 72h post-DFP. Diapocynin significantly reduces DFP-induced reactive astrogliosis, neurodegeneration, GP91phox, glutathiolated protein, serum nitrite, or pro-inflammatory cytokines and chemokines such as interleukins (IL) IL-1α, IL-6, IL-2, IL-17A, Leptin, IP-10 in the hippocampus[1].
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