AVN-944
CAS No. : 297730-17-7
(Synonyms: VX-944)
| Size | Price | Stock |
|---|---|---|
| 1mg | $68 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $740 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13560 |
| M.Wt: | 477.51 |
| Formula: | C25H27N5O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[1][2][3].
In Vitro:AVN-944 (0-1 μM, 48 h) inhibits growth of human multiple myeloma (MM) cell lines in a dose-dependent manner[1].
AVN-944 (800 nM, 0-72 h) induces apoptosis in MM cell lines via a caspase-independent, Bax/AIF/Endo G pathway[1].
AVN-944 (0-200 nM) enhances the cytotoxicity of Doxorubicin (HY-15142A) and Melphalan (HY-17575)[1].
AVN-944 inhibits the proliferation of the human MV-4-11 and murine Ba/F3-Flt3-ITD-dependent cell lines with IC50 values of 26 and 30 nM, respectively[2].
AVN-944 (0-32 μM, 48 h) shows good activity against arenavirus infection at low doses (7.5 μM) with less cytotoxicity[3].
AVN-944 (0-6.4 μM, 48 h) does not reduce the viability of peripheral blood mononuclear cells (PBMNCs)[1].
In Vivo:AVN-944 (0-150 mg/kg, Orally, twice daily) significantly increases the median survival time of leukemia model mice[2].
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