Dihydro-β-erythroidine (hydrobromide)
CAS No. : 29734-68-7
(Synonyms: DHβE (hydrobromide))
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| 10mg | $780 | In-stock |
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| Cat. No. : | HY-107670 |
| M.Wt: | 356.25 |
| Formula: | C16H22BrNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 8 mg/mL (ultrasonic;warming);H2O : 35 mg/mL (ultrasonic;warming) |
Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities[1][2][3].
In Vivo: Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 μL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf)[2].
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs)[4].
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