LDN-0044878
CAS No. : 296246-47-4
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| Cat. No. : | HY-118606 |
| M.Wt: | 434.56 |
| Formula: | C28H22N2OS |
| Purity: | >98 % |
| Solubility: |
LDN-0044878 is a PAK3 inhibitor. LDN-0044878 inhibits the proliferation or induces the death of p53-deficient cells. LDN-0044878 exhibits moderate trypanocidal activity against Trypanosoma brucei, but does not directly inhibit the core target Rhodesain. LDN-0044878 can be used in studies related to cervical adenocarcinoma and Trypanosoma brucei infection.
In Vitro:LDN-0044878 (75-150 h) reduces the viability of HeLa cells, with EC50 values of 10.7 μM (75 h), 15.5 μM (100 h) and 11.1 μM (150 h)[1].
LDN-0044878 (Compound 19) exhibits moderate trypanocidal activity, with an IC50 of 14.75 against T. brucei[2].
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