Roslin 2 (bromide)
CAS No. : 29574-21-8
(Synonyms: Benzylhexamethylenetetramine (bromide))
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| Cat. No. : | HY-A0280 |
| M.Wt: | 311.22 |
| Formula: | C13H19BrN4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1]. In Vitro: Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1]. In Vivo: Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].
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