L-006235
CAS No. : 294623-49-7
(Synonyms: L-235)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $1150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103352 |
| M.Wt: | 466.60 |
| Formula: | C24H30N6O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C) |
L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss[1][2].
IC50 & Target: IC50: 5 nM (cathepsin K)[1]
In Vitro: L-006235 inhibits bone resorption in the rabbit bone resorption assay, with an IC50 of 5 nM[1].
L-006235 (10 μM; 1 h) show a punctate fluorescence throughout the cytoplasm in HepG2 cells[2].
In Vivo: L-006235 (0.6-15 mg/kg; p.o. qd for 8-11 d) reduces N-telopeptides (NTx) and creatinine (Cre) by up to 76% dose-dependently in rhesus monkey[1].
L-006235 (20 mg/kg; p.o.) exhibits high oral bioavailability (68%), long terminal half-life (204 min) and Cmax (1.4 μM) in rats[1].
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