7-Nitroindazole

7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC₅₀ = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease^[1][2][3][4]. In Vitro:7-Nitroindazole (0.01-100 μM) has obvious inhibitory effect on cerebellar NOS (IC₅₀: 0.47 μM), and is more effective than L-NAME (HY-18729A) (IC₅₀: 0.87 μM) and L-NMMA (HY-18732) (IC₅₀: 2.37 μM)^[1]. In Vivo:7-Nitroindazole (10-80 mg/kg; Intraperitoneal injection; Single dose) has an anti-injury and anti-nociceptive effect in a formalin-induced mouse pain model without increasing blood pressure^[1].
7-Nitroindazole (25 mg/kg; Subcutaneous injection; 25 days) improves L-DOPA (HY-N0304)-induced dyskinesias in non-human primate models of Parkinson's disease^[2].
7-Nitroindazole (5-20 mg/kg; Intraperitoneal injection; 6 weeks) improves the learning and memory of hypothyroidism rats^[3].
7-Nitroindazole (30 mg/kg; Intraperitoneal injection; Single dose) enhances Fos immune response induced by muscle proprioceptive signaling within distinctive regions of the spinal cord in rats^[4].