Licarbazepine
CAS No. : 29331-92-8
(Synonyms: BIA 2-005; GP 47779)
| Size | Price | Stock |
|---|---|---|
| 100mg | $26 | In-stock |
| 250mg | $47 | In-stock |
| 1g | $98 | In-stock |
| 5g | $457 | In-stock |
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| Cat. No. : | HY-108506 |
| M.Wt: | 254.29 |
| Formula: | C15H14N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects[1].
IC50 & Target: Sodium Channel[1]
In Vivo: Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification[1].
ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge.?ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC)[1].
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