Deoxyelephantopin
CAS No. : 29307-03-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $300 | In-stock |
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| Cat. No. : | HY-N2491 |
| M.Wt: | 344.36 |
| Formula: | C19H20O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].
IC50 & Target: NF-κB, MAPK, PI3K/Akt, β-catenin
In Vitro: Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1].
Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].
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