25,26-Dihydroxyvitamin D3

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia^[1][2][3]. In Vivo:25,26-Dihydroxyvitamin D3 (intravenous injection) shows no significant anti-rachitic activity in rats; if any such activity exists, it must be lower than 4 IU/μg^[2].
25,26-Dihydroxyvitamin D3 (0.25 μg; intravenous injection) does not stimulate bone mineral mobilization in rats fed a low-calcium diet, but it significantly increases intestinal calcium transport, with an activity approximately half that of 25-HCC^[2].
25,26-Dihydroxyvitamin D3 (650 pmol; jugular vein injection) induces a significant, rapid, and sustained decrease in serum Ca²⁺ that lasts for 48 h in vitamin D-deficient, phosphorus-deprived rats^[3].
25,26-Dihydroxyvitamin D3 (325 pmol; i.p.; for 5 consecutive days) significantly increases the serum Ca²⁺ level in vitamin D-deficient rats (p < 0.01)^[3].