Adenine (hydrochloride)
CAS No. : 2922-28-3
(Synonyms: 6-Aminopurine (hydrochloride); Vitamin B4 (hydrochloride))
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| Cat. No. : | HY-B0152A |
| M.Wt: | 171.59 |
| Formula: | C5H6ClN5 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
IC50 & Target:Target: Human Endogenous Metabolite
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Adenine hydrochloride can be used to induce chronic liver injury models. Pharmacokinetic data show that in adult male Sprague-Dawley rats, 20-30 minutes after administration (10 mg/kg, i.v.), the Adenine content in blood dialysate samples is 0.78 μg/mL[4].
Administration: 0.2% Adenine in diet; 3 weeks
Rat: Sprague-Dawley (SD) • male • 8 weeks of age
Administration: 0.5% Adenine in diet; 3 weeks
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