OM137
CAS No. : 292170-13-9
Price and Availability of
CAS No. : 292170-13-9
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|---|---|---|
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| Cat. No. : | HY-123279 |
| M.Wt: | 306.34 |
| Formula: | C13H14N4O3S |
| Purity: | >98 % |
| Solubility: |
Introduction of
292170-13-9
:
OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes[1].
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