(E/Z)-IT-603
CAS No. : 292168-90-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $215 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $630 | In-stock |
| 100mg | $890 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-121508 |
| M.Wt: | 329.17 |
| Formula: | C11H9BrN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].
In Vitro: (E/Z)-IT-603 (10 μM) reverses the effects of ESAT-6 on the Treg generation in FACS-sorted CD+CD25- conventional T cells via blocking c-Rel[2].
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