Mequitazine
CAS No. : 29216-28-2
(Synonyms: LM-209)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $190 | In-stock |
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| Cat. No. : | HY-B2168 |
| M.Wt: | 322.47 |
| Formula: | C20H22N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 16 mg/mL (ultrasonic;warming) |
Mequitazine is a potent, and long-acting histamine H1 antagonist. In Vitro: Mequitazine is a potent H1-receptors selective antihistaminic drug widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced[2]. In Vivo: Mequitazine and clemizole antagonize the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity[3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta[4].
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