IMB-XH1
CAS No. : 292057-76-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $290 | In-stock |
| 10mg | $450 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1680 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12826 |
| M.Wt: | 333.41 |
| Formula: | C19H15N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1)[1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively[2]. IC50 & Target:Mcl-1[1] In Vitro: IMB-XH1 (Compound 2) is a Mcl-1 inhibitor[1]. IMB-XH is screened out with the IC50 value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens[2].
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