PG 116800
CAS No. : 291533-11-4
(Synonyms: PG 530742; PGE 530742; PGE 7113313)
| Size | Price | Stock |
|---|---|---|
| 5mg | $600 | In-stock |
| 10mg | $858 | In-stock |
| 25mg | $1350 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-14240 |
| M.Wt: | 501.55 |
| Formula: | C24H27N3O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction[1][2].
In Vitro:PG 116800 exhibits high binding affinity for purified MMP-2, -3, -8, -9, -13, and -14, and low affinity for purified MMP-1 and -7[1].
In Vivo:PG 116800 (3 or 6 months) causes joint swelling and collagen accumulation in rats, with reversible effects following treatment discontinuation[1].
PG 116800 (12 months) causes joint swelling, collagen accumulation, periosteal fibrous tissue proliferation, and bone resorption in dogs, with reversible effects following treatment discontinuation[1].
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