Atenolol
CAS No. : 29122-68-7
(Synonyms: (RS)-Atenolol)
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
| 1g | $64 | In-stock |
| 5g | $161 | In-stock |
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| Cat. No. : | HY-17498 |
| M.Wt: | 266.34 |
| Formula: | C14H22N2O3 |
| Purity: | >98 % |
| Solubility: | H2O : 8.33 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].
In Vitro:Atenolol (1-100 μM, 5 h) strengthenes the inhibitory effect on cell migration of rat aortic smooth muscle cells when combinated with Nifedipine (HY-B0284) (1-100μM)[3].
Atenolol (50-150 μM, 24 h) decreases the cell surival of Hem-ECs in a dose-dependent manner[4].
In Vivo:Atenolol (5-20 mg/kg, i.g., one time) combinated with Amlodipine (HY-B0317) can reduce and stabilize blood oressure (BP) in 2K1C renovascular hypertensive rats[5].
Atenolol (6 mg/kg, p.o., one time) combinated with Nifedipine (HY-B0284) prevents ZD6126-induced cardiac necrosis and increases plasma troponin T levels[6].
Atenolol (40 mg/kg, p.o., daily, 6 weeks) increased plasma membrane β1- and β2- adrenoceptors density in rats[7].
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