Avosentan (Standard)
CAS No. : 290815-26-8
(Synonyms: Ro 67-0565 (Standard); SPP-301 (Standard))
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| Cat. No. : | HY-15195R |
| M.Wt: | 479.51 |
| Formula: | C23H21N5O5S |
| Purity: | >98 % |
| Solubility: |
Avosentan (Standard) is the analytical standard of Avosentan (HY-15195). This product is intended for research and analytical applications. Avosentan is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction, and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure.
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