7,3',4'-Tri-O-methylluteolin
CAS No. : 29080-58-8
(Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone)
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| Cat. No. : | HY-N7012 |
| M.Wt: | 328.32 |
| Formula: | C18H16O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities[1][2][3]sup>[4]sup>[5].
In Vitro:In LPS (1 µg/mL)-induced RAW 264.7 macrophages, 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) (1-40 µg/mL) significantly inhibits nitric oxide production and demonstrats slight reduction in prostaglandin-E2 level at tested concentrations. 7,3',4'-Tri-O-methylluteolin reduces the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β[1].
7,3',4'-Tri-O-methylluteolin (40 µg/mL; 24 h) significantly induces reduction in the mRNA expressions of iNOS synthase and COX-2 in RAW 264.7 cells[1].
7,3',4'-Tri-O-methylluteolin has antioxidant effects and can scavenge free radicals, superoxides, and hydroxyl radicals[2].
7,3',4'-Tri-O-methylluteolin (5-15 μg/mL; 24-48 h) induces cytotoxicity in the treated cells, which correspondingly resulted in the IC50 values of 12 μg/mL and 8 μg/mL after 24 and 48 h treatment[3].
7,3',4'-Tri-O-methylluteolin (8-12 μg/mL; 24-48 h) induces apoptosis in MCF-7 cells. 7,3',4'-Tri-O-methylluteolin induces the phosphatidylserine translocation, DNA damage and the significant elevation of cellular ROS[3].
7,3',4'-Tri-O-methylluteolin (8-12 μg/mL; 24-48 h) encourages apoptosis through the modulation of apoptotic markers, such as p53, Bcl-2, Bax, and cleaved PARP. 7,3',4'-Tri-O-methylluteolin shifts the Bax:Bcl-2 ratio[3].
7,3',4'-Tri-O-methylluteolin shows activities against Candida albicans, Candida krusei and Candida galabrata[4].
7,3',4'-Tri-O-methylluteolin inhibits Trypanosoma brucei with a MIC value of 19.0 μM[5].
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