Prednimustine


CAS No. : 29069-24-7

(Synonyms: Leo 1031; NSC 134087)

29069-24-7
Price and Availability of CAS No. : 29069-24-7
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Cat. No. : HY-13732
M.Wt: 646.64
Formula: C35H45Cl2NO6
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 29069-24-7 :

Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research[1]. In Vivo:Prednimustine (120 mg/kg; s.c.; single dose) shows much less toxic than equimolar doses of Chlorambucil (HY-13593) (60 mg/kg; s.c.; single dose) in non-tumour-bearing rat model, due to differences in alkylating agent pharmacokinetics[1].
Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites[1].
Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma[1].

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