Hymeglusin
CAS No. : 29066-42-0
(Synonyms: F-244; 1233A; L-659699)
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| 1mg | $480 | In-stock |
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| Cat. No. : | HY-117430 |
| M.Wt: | 324.41 |
| Formula: | C18H28O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3]. IC50 & Target: IC50: 1.2 μM (HMG-CoA)[2][3] In Vitro: Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC50/IC50) of Hymeglusin is 11. The EC50 of Hymeglusin in K562 cells is 4.5 μM[1]. In Vivo: At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2].
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