Daun02
CAS No. : 290304-24-4
| Size | Price | Stock |
|---|---|---|
| 2mg | $150 | In-stock |
| 5mg | $265 | In-stock |
| 10mg | $430 | In-stock |
| 25mg | $860 | In-stock |
| 50mg | $1376 | In-stock |
| 100mg | $2200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13061 |
| M.Wt: | 884.79 |
| Formula: | C41H44N2O20 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor. IC50 & Target: Topoisomerase[1][2] In Vitro: Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca2+)-dependent action potentials in neuroblastoma cells[1]. Daunorubicin is a topoisomerase inhibitor[2]. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively[3]. In Vivo: Daun02 is a good substrate for β-gal with Km and Vmax values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin[3].
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