Arimoclomol (maleate)
CAS No. : 289893-26-1
(Synonyms: BRX-220)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $500 | In-stock |
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| Cat. No. : | HY-106443A |
| M.Wt: | 429.85 |
| Formula: | C18H24ClN3O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol maleate can be used for the study of Niemann–Pick disease type C. IC50 & Target:HSP[1] In Vivo:Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].
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