Jacaric acid
CAS No. : 28872-28-8
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| Cat. No. : | HY-121619 |
| M.Wt: | 278.43 |
| Formula: | C18H30O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator[3]. Jacaric acid is orally active.
In Vitro:Jacaric acid (0-10 μM) dose- and time-dependently induces apoptosis in cells PC-3 and LNCaP, through an intrinsic and an intrinsic and extrinsic pathway, respectively[1].
Jacaric acid (0-10 μM) induces cytotoxicity in DLD-1 cells through intracellular incorporation and induction of apoptosis via lipid peroxidation[2].
Jacaric acid (50-100 μM) activates the macrophage through secretion of cytokines IFN-γ, IL-1β and TNF-α, enhances the endocytic activity in murine peritoneal macrophages and induces the cytostatic activity in MBL-2 cells[3].
In Vivo:Jacaric acid (1 mg/day/mouse, p.o. for 36 days) exhibits antitumor activity in DLD-1 transplanted athymic nude mice, without significant toxicity[2].
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