Leu-AMS
CAS No. : 288591-93-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $228 | In-stock |
| 5mg | $708 | In-stock |
| 10mg | $1068 | In-stock |
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| Cat. No. : | HY-108900 |
| M.Wt: | 459.48 |
| Formula: | C16H25N7O7S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 49.17 mg/mL |
Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria[1]. IC50 & Target: IC50: 22.34 nM (LRS)[1] In Vitro: Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].
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