Lithospermic acid
CAS No. : 28831-65-4
(Synonyms: (+)-Lithospermic acid)
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|---|---|---|
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| 10mg | $154 | In-stock |
| 25mg | $308 | In-stock |
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| Cat. No. : | HY-N0823 |
| M.Wt: | 538.46 |
| Formula: | C27H22O12 |
| Purity: | >98 % |
| Solubility: | H2O : 66.67 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo[1].
In Vitro: Lithospermic acid (100 μM, 24 h) promotes the expression of eNOS and the phosphorylation of AMPKα, activates Nrf2/HO-1 signaling pathways, exhibits antioxidant and anti-apoptotic activities[2].
Lithospermic acid (16 μg/mL, 30 min) is the competitive inhibitor for xanthine oxidase, that inhibits uric acid production with an IC50 of 5.2 µg/mL, inhibits superoxide radicals (SOR) production with an IC50 of 1.08 µg/mL[3].
In Vivo: Lithospermic acid (50 mg/kg, po for 6 days) exhibits cardioprotective efficacy against MI/R injury in mouse models[2].
Lithospermic acid (10-30 mg/kg, po, single dose) exhibits uric acid lowering and anti-inflammatory effects in rats hyperuricemia and gouty arthritis models[3].
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