Lithospermic acid (Standard)

Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo^[1]. In Vitro:Lithospermic acid standard (100 μM, 24 h) promotes the expression of eNOS and the phosphorylation of AMPKα, activates Nrf2/HO-1 signaling pathways, exhibits antioxidant and anti-apoptotic activities^[2].
Lithospermic acid standard (16 μg/mL, 30 min) is the competitive inhibitor for xanthine oxidase, that inhibits uric acid production with an IC₅₀ of 5.2 µg/mL, inhibits superoxide radicals (SOR) production with an IC₅₀ of 1.08 µg/mL^[3].
In Vivo:Lithospermic acid standard (50 mg/kg, po for 6 days) exhibits cardioprotective efficacy against MI/R injury in mouse models^[2].
Lithospermic acid standard (10-30 mg/kg, po, single dose) exhibits uric acid lowering and anti-inflammatory effects in rats hyperuricemia and gouty arthritis models^[3].