alpha-Asarone
CAS No. : 2883-98-9
(Synonyms: α-Asarone; trans-Asarone)
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| 25g | $130 | In-stock |
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| Cat. No. : | HY-N0700 |
| M.Wt: | 208.25 |
| Formula: | C12H16O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. In Vitro:The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells[2]. In Vivo:The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity[1].
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