3,4-Dihydroxyphenylglycol

3,4-Dihydroxyphenylglycol is a phenolic compound and antioxidant. 3,4-Dihydroxyphenylglycol can be extracted from olive oil. 3,4-Dihydroxyphenylglycol downregulates the expression of proinflammatory enzymes (iNOS, COX-2) and prevents the degradation of IκBα. 3,4-Dihydroxyphenylglycol has antioxidant properties. 3,4-Dihydroxyphenylglycol has shown positive effects on frozen-thawed ram sperm. 3,4-Dihydroxyphenylglycol can be used in the study of inflammatory-related diseases (such as ulcerative colitis) and reproductive health (sperm cryopreservation)^[1][2][3]. In Vitro:3,4-Dihydroxyphenylglycol (50-100 μM) reduces nitrite production, downregulates iNOS and COX-2 expression, and prevents IκBα degradation in LPS-stimulated mouse peritoneal macrophages^[1].
3,4-Dihydroxyphenylglycol exhibits antioxidant activity with an IC₅₀ of 1.55 μM in a DPPH free radical scavenging assay^[1].
3,4-Dihydroxyphenylglycol (10-70 μg/mL) exhibits positive effects on frozen-thawed ram spermatozoa, reducing LPO^[2].
In Vivo:3,4-Dihydroxyphenylglycol (0.1%; mixed in standard feed; p.o.) has no significant effect on improving colitis symptoms such as weight loss, increased disease activity index, and colon shortening in the DSS-induced acute colitis model of C57BL/6 mice^[3].