Oxcarbazepine
CAS No. : 28721-07-5
(Synonyms: GP 47680)
| Size | Price | Stock |
|---|---|---|
| 25g | $55 | In-stock |
| 100g | $164 | In-stock |
| 500g | $494 | In-stock |
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| Cat. No. : | HY-B0114 |
| M.Wt: | 252.27 |
| Formula: | C15H12N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3]. IC50 & Target:Sodium Channel[1]. In Vitro: Oxcarbazepine significantly inhibits glioblastoma cell growth and reaches IC50 at therapeutic concentrations. The IC50s of Oxcarbazepine screened with the U87 and T98 cell lines are 12.35 and 9.45 μg/mL,respectively[2]. In Vivo: Oxcarbazepine protectes mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward this anticonvulsant effect is observed when rats are treated with Oxcarbazepine daily for 4 weeks.
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