Sotolone

Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC₅₀ values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro^[1][2]. In Vitro:Sotolone (200 µg/mL; 2-6 days) exhibits weak to moderate in vitro inhibitory activity against Magnaporthe oryzae BV, Sclerotium rolfsii, and Phytophthora capsici, with IC₅₀ values of 256.0 µg/mL, 333.7 µg/mL, and 279.2 µg/mL respectively, and weaker activity against other tested phytopathogenic fungi^[2].