Nigericin (sodium salt)

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K⁺/H⁺ ionophore, promoting K⁺/H⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC^{[1][2][3][4][5][6][7]}. In Vitro:Nigericin (0-4 μg/mL; 24 h) sodium salt induces pyroptosis through caspase 1/GSDMD pathway in TNBC cells^[6].
Nigericin (1 μg/mL, 8 × MIC; 2 μg/mL, 16 × MIC; 196 h) sodium salt is a bactericidal antibiotic against MDR gram-positive bacteria^[4].
Nigericin (0-0.25 μg/mL; 24 h) sodium salt inactivates Wnt/β-catenin pathway in H460 cells as an anti-cancer effect^[7].
In Vivo:Nigericin (1 mg/kg; i.p.; every 12 h for 3 D) sodium salt reduces the infection of S. aureus USA300 in mice^[4].
Nigericin (0.025 mg/kg; s.c.; every two days in 4 weeks) sodium salt plus anti-PD-1 shows synergistic anti-cancer effect^[6].