Nigericin (sodium salt) (Standard)

Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K⁺/H⁺ ionophore, promoting K⁺/H⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC^{[1][2][3][4][5][6][7]}. In Vitro:Nigericin (0-4 μg/mL; 24 h) sodium salt induces pyroptosis through caspase 1/GSDMD pathway in TNBC cells^[6].
Nigericin (1 μg/mL, 8 × MIC; 2 μg/mL, 16 × MIC; 196 h) sodium salt is a bactericidal antibiotic against MDR gram-positive bacteria^[4].
Nigericin (0-0.25 μg/mL; 24 h) sodium salt inactivates Wnt/β-catenin pathway in H460 cells as an anti-cancer effect^[7].
In Vivo:Nigericin (1 mg/kg; i.p.; every 12 h for 3 D) sodium salt reduces the infection of S. aureus USA300 in mice^[4].
Nigericin (0.025 mg/kg; s.c.; every two days in 4 weeks) sodium salt plus anti-PD-1 shows synergistic anti-cancer effect^[6].