S-14506 (hydrochloride)
CAS No. : 286369-38-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $830 | In-stock |
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| Cat. No. : | HY-110024 |
| M.Wt: | 443.94 |
| Formula: | C24H27ClFN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3].
In Vitro:S-14506 hydrochloride serves as 5-HT1A receptor agonist, appearing to be G(i) protein-dependent[4].
S-14506 hydrochloride (0.1 nM-100 μM; 10 min) shows high affinity for the G protein-uncoupled state of the 5-HT receptor in HeLa cells with pertussis toxin treatment[4].
In Vivo:S-14506 hydrochloride (0.2-3.38 mg/kg; IP; single dose) dose dependently antagonizes Apomorphine (0.75 mg/kg, s.c.) induced stereotyped climbing and sniffing in mice. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors[2].
S-14506 hydrochloride (0.63 mg/kg; SC; single dose) is active in forced swimming test in rats. It induces imobility in rats[3].
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