Desmethylicaritin
CAS No. : 28610-31-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $300 | In-stock |
| 5mg | $750 | In-stock |
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| Cat. No. : | HY-N2785 |
| M.Wt: | 354.35 |
| Formula: | C20H18O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway[1][2].
In Vitro:Desmethylicaritin is a bioactive metabolite of Epimedium flavonoids in serum[1].
Desmethylicaritin (0.1, 1, and 10 μM; 48 h) suppresses the adipogenesis and inhibited clonal expansion during adipogenesis in 3T3-L1 cells in a dose-dependent manner[1].
Desmethylicaritin (10 μM; 48 h) does not affect CCAAT/enhancer binding protein δ and β mRNA expression, but decreases the mRNA expression of CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein and lipoprotein lipase[1].
Desmethylicaritin (10 μM; 2, 4, 6, and 10 d) increases the protein expression of β-catenin both in the cytoplasm and nuclei and immunofluorescence results confirmed that desmethylicaritin increased nuclear translocation of β-catenin[1].
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